1. Incorrect reset circuit
2. Unstable -12V under load. 1k resistor should be added between +12V and GND
3. BIOS PLCC socked interferes with CF card slot
4. U15 should be TXS0104PW
5. Incorrent IRQ routing for COM3 and COM4
6. U17 should not be installed
7. Incorrect CTS/RTS connection on ESP8266
8. C3 should not be installed